Technology

2008-12-31T02:19:53Z

68.163.174.136: /* pic */

==pic==
http://www.rentron.com/Myke3.htm

http://www.play-hookey.com/digital/jk_nand_flip-flop.html

http://www.digital-diy.net/16F%20Examples/LM35DZ.aspx

[http://www.opencircuits.com/Main_Page open source circuits wiki]

[http://www.sparkfun.com/commerce/tutorials.php sparkfun hobby shop]

[http://www.batchpcb.com/index.php/Home batchpcb.com pcb fabrication]

[http://www.avrfreaks.net/index.php?module=Freaks%20Devices&func=displayDev&objectid=78 AVR is alternative to PIC]

[http://www.sparkfun.com/commerce/tutorial_info.php?tutorials_id=57 a good tutorial on embedded systems]
:Google any of these for more info. I have chosen the ATmega168 as the learning IC of choice. Why?

* 20 MIPs (million instructions per second!) is powerful enough to do some really cool projects
* It's cheap! $2.13 currently
* It's got all the goodies under the hood (UART, SPI, I2C, ADC, internal osc, PWM, kitchen sink, etc)
* 16K of program memory is enough for almost any beginner project
* The tools are free! (C compilers for many of the other micros cost a lot of money)
* The programming and debugging tools are low cost ($20 will get you started)

[http://www.evilmadscientist.com/article.php/avrtargetboards evil mad scientist on AVR programming]

==isp==
host
206.71.150.94

http://www.networksolutions.com/whois/index.jsp

http://www.namecheap.com/myaccount/index.asp mckennatim nanj

https://thenynocportal.com/clientarea.php

==making transparent in gimp==
1. open image

2. Right click the image and go to LAYERS then ADD ALPHA CHANNEL. You won't notice anything happening, but don't be concerned. It basically adds a transparent layer at the bottom of your image so when we erase the colors.....it's shows the transparent layer. Which of course would show whatever was under it on the screen.

3. Right click on the image again and go to SELECT and then down to BY COLOR. A window that is all black opens up. Don't change any of the settings....just use the defaults for now.

4. Now click on the color in the image you want to be transparent. These colors will now show up outlined.

5. Right click on the image again and go to EDIT and then down to CLEAR. This should now erase the outlined color you just picked from the image and the "transparent gimp checkerbox" should show through. This is the Gimps way of showing you that section is now transparent.

6. Right click on the image and choose SAVE AS and make sure to save as a GIF file if you want the transparency to work on the web.

==embedding video==
1. find the file Sanitizer.php in the folder /includes of your mediawiki installation
2. find the function removeHTMLtags in that file. below that you’ll find a list of whitelisted HTML tags. add the tag embed to the list.
3. find the function setupAttributeWhitelist in the same file. several lines below you will find HTML-attributes being whitelisted for each HTML tag. so you add a new line (maybe below the line that defines span):
‘embed’ => array( ’style’, ‘id’, ‘type’, ’src’, ‘width’, ‘height’ ),

take care to replace the typographic ‘-quotes by straight ones when doing copy&paste. (wordpress converts the quotes on this blog, so you need to convert them back.)

you’re done. now you can copy the HTML-code provided by google or youtube into your wiki textbox and it’ll work. (make sure to make backups and document so you know what you’ve changed. when upgrading you’ll have to repeat the process. no warranties for possibile security leaks resulting from the hack.)

update april 2007: i just tested, this hack also works with mediawiki 1.9.2, just that you need to add embed to $htmlpairs. (note: in case the embed-code you want to use has the format <embed /> you now have to convert it to <embed> </embed> before posting it to your wiki.) i also would recommend to paste the last line of code near br instead of span (the file has got rearranged a bit).
==mediawiki memory problem==
php.ini is in public_html, it has to be copied into everywhere that uses php
left ini_set commented out in localsettins.php
.htaccess php_mem ... didn't work
==mediawiki upgrade==
http://www.g-loaded.eu/2006/09/05/mediawiki-upgrade-procedure/
easy way:
*goto maintainance directory and run php dumpBackup.php --current> dumfile.xml
*on new site install wiki, put dumpfile.xml on its maintenance dir run php importDump.php dumfile.xml

==css==
*sitewide changes go in Mediawiki:Monobook.css
*user changes go in User:MrMcKenna/monobook.css
==lynx==
==[[Moving_from_shared_to_VPS]]==

Lani

2008-12-31T00:26:57Z

68.163.174.136:

<blockquote style="border: 0px solid blue; padding: 2em;">
"Nearly 20% of women with metastatic breast cancer live five years or longer. The survival rate is 16%. This is based on statistics. Each woman is unique and her situation will also be unique." - http://imaginis.com Women's Health Resource.
</blockquote>
=====stage IV breast cancer=====
The primary cancer has spread out of the breast to other parts of the body (metastasized) (to in this case, the liver).
;[http://www.webmd.com/breast-cancer/stage-4-treatment-options from WebMD]:"So far, treatment of stage IV breast cancer does not provide a cure for the disease. By shrinking the cancer, treatment can slow down the disease, make you feel better, and let you live longer. Although patients with stage IV breast cancer may live for years, it is usually life-threatening at some point."
;[http://capitalgastro.com/ Capital Gastro forms]:

====current treatment====
The current treatment includes chemotherapy(Taxotere) in conjunction with a designer drug(Herceptin) for cells whose Hercep Test shows 60% Her2 3+. Types: adino carcinoma(liver), infiltrating duct carcinoma(breast)
;[http://www.cancer.org/docroot/CRI/content/CRI_2_4_4X_Treatment_by_Stage_Breast_Cancer_5.asp?sitearea= cancer.org] - on trastuzumab (Herceptin):"Stage IV cancers have spread beyond the breast and lymph nodes to other parts of the body. While surgery and/or radiation may be useful in some situations (see below), they are very unlikely to cure these cancers, so systemic (non-targeted) therapy is the main treatment. Depending on many factors, this may consist of hormone therapy, chemotherapy, targeted therapies such as trastuzumab (Herceptin) or bevacizumab (Avastin), or some combination of these treatments.<br /><br />Trastuzumab may help women with HER2-positive cancers live longer if it is given with the first chemotherapy for stage IV disease. It is not yet known whether it also should be given at the same time as hormone therapy, or how long a woman should remain on therapy."

In November 2006, the FDA approved Herceptin as part of a treatment regimen.

=====how does herceptin work=====
http://www.gene.com/gene/products/information/oncology/herceptin/images/moa.jpg

Herceptin seems to be one of those designer drugs that just happens to drift into and bond to a target cell. In this case the target cell is called Her2.

The way Her2 wants to work is to pair up and go through the cell wall. In that orientation it provides some (mysterious) chemical signaling to the cells nucleus telling it it's time to divide and reproduce itself. Overexpression on Her2 (that there is too many of them) is what causes a healthy breast cell to go ballistic.

The plan is to bind to her2 and prevent it from pairing up and signaling the nucleus. When the herceptin binds, it not only prevents pairing and signaling, it also causes the Her2 protein to want to withdraw into the cell. In addition, the herceptin bound cancer cell is seen by the immune system as a problem cell and the immune system goes after it. Not only can the Her2 protein not signal, the whole cancer cell gets attacked.

=====Common side effects of Herceptin include: (from [http://www.imaginis.com/breasthealth/herceptin.asp imaginis])=====
* Fever
* Chills
* Weakness
* Nausea (especially when given with chemotherapy)
* Diarrhea
* Increased cough
Less common side effects of Herceptin include:
* Heart problems (see explanation below)
* Loss of white blood cells (leukopenia)
* Fatigue or difficulty breathing due to a reduction of red blood cells (anemia)
=====[http://www.taxotere.com/oncology/about_Taxotere/mechanism_of_action.aspx chemo using Taxotere] =====
This is a cell showing microtubule structures as it is about to divide:
http://www.taxotere.com/images/clinical_pharmacology_dividing_cell_new.jpg
The antitumor activity of Taxotere® (docetaxel) is derived from its ability to disrupt the normal process of microtubule assembly and disassembly.*,1,2

Microtubules are cylindrical structures that form the basis of the cellular skeleton and are essential to the reproduction, growth and spread of tumor cells.*,1 Normally, as a part of the mitotic process, microtubules are reorganized to form a spindle. Assembly of microtubules from tubulin requires the presence of guanosine triphosphate (GTP).*,1,2

Taxotere® binds tubulin, promoting polymerization and preventing depolymerization of microtubules in the absence of GTP.*,2 It binds to the ß-subunit of the tubulin within the microtubule, promoting the formation of stable microtubules, which form abnormal bundles that do the following:

* Resist physiologic disassembly
* Accumulate within tumor cells
* Inhibit cell proliferation leading to cell death

http://www.taxotere.com/images/mechanism_action_microtubule.jpg

;[http://www.imaginis.com/breasthealth/bc_drugs4.asp#Taxotere chemo drug] Taxotere (docetaxel):Taxotere (generic name, docetaxel) is a cancer drug that resembles Taxol in chemical structure. Taxotere was FDA approved in 1996 to treat advanced breast cancer in patients who have not responded well to chemotherapy with the drug, doxorubicin. In 1998, Taxotere was also approved by the FDA to treat breast cancer that has spread into other areas of the breast or to other parts of the body after treatment with standard chemotherapy. Docetaxel inhibits the division of breast cancer cells by acting on the cell’s internal skeleton. The drug is usually given intravenously (through the vein) once every three weeks. Each treatment typically takes around one hour, though the dosage will vary depending on the patient’s medical situation.

======Possible side effects of Taxotere include:======
* Decrease in white blood cells (leukopenia)
* Fever (often a warning sign of infection)
* Fluid retention
* Allergic reactions
* Hair loss

=====CellSearch CTC -a new blood test=====
;[http://www.imaginis.com/breasthealth/metastatic2.asp (Metastatic) Breast Cancer] CTC test: "A new blood test, called CellSearch CTC, shows promise in helping to manage treatment of metastatic breast cancer. The test measures the number of tumor cells circulating in a sample of blood and can immediately inform physicians if a patient's treatment is working or needs modification. Research has shown that if a patient typically has more than five CTCs in a blood sample, survival may be shorter compared to patients with no CTCs. The CTC test can help physicians monitor whether a patient's treatment by determining whether the number of cancer cells is decreasing. This information can help determine whether changes are needed in a patient's treatment. While the test is used independently-typically before each chemotherapy treatment cycle-health experts do not recommend that it replace existing tests to monitor disease progression, such as the CAT scan or PET scan. Instead, it can be a useful supplement to those tests, which are often administrated every 12 to 24 weeks. Click here to learn more about the CTC test."
=====palliative care (redefined)=====
;[http://www.cancer.gov/cancertopics/advancedcancer/ coping with advanced cancer pamphlet] - on comfort (palliative) care: "You have a right to comfort care both during and after treatment. This kind of care is often called palliative care. It includes treating or preventing cancer symptoms and the side effects caused by treatment. Comfort care can also mean getting help with emotional and spiritual problems during and after cancer treatment. Sometimes patients don't want to tell the doctor about their symptoms. They only want to focus on the cancer. Yet you can improve your quality of life with comfort care.<br /><br /> People once thought of palliative care as a way to comfort those dying of cancer. Doctors now offer this care to all cancer patients, beginning when the cancer is diagnosed. You should receive palliative care through treatment, survival, and advanced disease. Your oncologist may be able to help you. But a palliative care specialist may be the best person to treat some problems. Ask your doctor or nurse if there is a specialist you can go to."

Physicians at major academic medical centers worldwide rely on UpToDate's complete and current medical information to answer their clinical questions

====uptodate.com -providers site====
http://www.uptodate.com/patients/content/search.do?search=Breast+Cancer&source=USER_INPUT&searchOffset=&_NEXTITEM=&_EVENTNAME=Go&_EVENTARG=undefined&_POSTBACK=true&_DESTINATION=&_xCoordHolder=0&_yCoordHolder=70

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Technology

Lani